This book describes the role of advanced neuroimaging techniques in characterizing the changes in tissue structure in patients with brain metastases. On a large number of newly recognized CT, MRI, and PET characteristics of brain metastases from different primary tumors are highlighted, thereby elucidating the potential differential diagnostic role of CT perfusion imaging, MR spectroscopy, MR diffusion-weighted imaging, MR susceptibility-weighted imaging, and PET with different radiopharmaceuticals. For example, the different manifestations of metastases of melanoma, renal cell carcinoma, and ovarian cancer on MRI and CT perfusion imaging are described, and the role of MR susceptibility-weighted imaging in the differential diagnosis of glioblastoma multiforme and metastatic tumors is clarified. Metastases of colon cancer have shown a special manifestation on T2 weighted images. The book also presents novel findings regarding pathogenesis and tumor biology and describes qualitative and quantitative changes in tumor tissue and alterations in brain white matter due to surrounding tumor growth.

Neuroradiologists and others, including neurosurgeons, neurologists, and nuclear medicine physicians, will find that this book offers a fascinating insight into the ways in which newly available data on structural, hemodynamic, and metabolic changes are enriching the neuroimaging of brain metastases.

Mikhail Dolgushin, M.D., Ph.D., Professor of Russian Academy of Science, Head of PET department, Russian Oncology Scientific Center, Moscow. Professor Dolgushin is the author of more than 100 scientific publications.

V.N. Kornienko, MD, PhD, is a famous Russian neuroradiologist and former Head of the Neuroimaging Department of the Burdenko Neurosurgical Institute. He is an academician of the Russian Academy of Science and a full member of the Russian and American Societies of Neuroradiology. Professor Kornienko is the author of 21 monographs (including two published by Springer) in the field of neuroradiology as well as more than 500 scientific publications.

I.N. Pronin, MD, PhD, is head of the Neuroimaging Department at the Burdenko Neurosurgical Institute of the Russian Ministry of Health. Professor Pronin is an Associate Member of the Russian Academy of Science. He is the author of 14 monographs in the field of neuroradiology (including two published by Springer) and more than 350 scientific publications.

Clinical and Prognostic Value of Neuroimaging in Metastatic Brain Tumors.- Clinical Evaluation and Neuroimaging Methods.- MR-Characteristics of Brain Metastases of Different Primary Tumors.- CT-Perfusion in Diagnostic of Brain Metastases.- PET Evidence of Cancer throughout the Body and Brain.- Differential Diagnosis between Primary and Secondary Brain Tumors.