InhaltsangabeVorwort/Preface I BERICHT UND SCHLUSSFOLRGERUNGEN II REPORT AND CONCLUSIONS III CONTRIBUTIONS Visions on toxicity testing in the 21st century Safety assessment of botanicals and botanical preparations used as ingredients in food supplements In silico toxicology screening of the rodent carcinogenic potential of phytochemicals using QSAR analysis Testing compuational toxicology models with phytochemicals In silico models to establish level of safety concern in absence of sufficient toxicological data In silico mehtods for physiologically based biokinetic models describing bioactivation and detoxification of coumarin and estragole; implications for risk assessment In vitro models for carcinogenicity testing - reality or fantasy? Carcinogen specific expression profiling: prediction of carcinogenic potential? Safety and biological efficacy testing of phytochemicals: an industry approach Metabolite profiling in rat plasma as a potential new tool for the assessment of chemically induced toxicity Profiling techniques in nutrition and food research The complex links between dietary phytochemicals and human health deciphered by metabolomics Antioxidative and antigenotoxic properties of vegetables and dietary phytochemicals: the value of genomics biomarkers in molecular epidemiology The Japanese toxicogenomics project: application of toxicogenomics Toxicology and risk assessment of coumarin: focus on human data Risk from furocoumarins in food ? ? An exposure assessment Transcriptome analysis in benefit-risk assessment of micronutrients and bioactive food components Colorectal and prostate cancer: The role of candidate genes in nutritional pathways Glucosinolates: DNA adduct formation in vivo and mutagenicity in vitro Defense mechanisms against toxic phytochemicals in the diet of domestic animals POSTERS Coumarin risk assessment: Lessons from human data Coffee and coffee compounds are effective antioxidants in human cells and in vivo Studying absorption, distribution, metabolism, and excretion of a complex extract Polyphenolic apple extracts and their constituents modulate DNA strand breaks and oxidation damage in human colon carcinoma cells Comparative evaluation of experimental data on a-amylase inhibition by flavonoids using molecular modelling Potential risk of furan in foods Comparative study on the toxicity of alternariol and alternariol monomethyl ether in human tumor cells of different origin A role for resveratrol and curcumine in sensitization of glioblastoma cells to genotoxic stress induced by alkylating chemotherapeutics BfRriskassessment of alkaloids as ingredients and contaminants of food: quinine, opium alkaloids, senecio pyrrolizidine alkaloids Elucidation of the genotoxic activity of the alkaloid ellipticine in human cell lines Dietary supplements and herbal medicinal products ? for a clear differentiation. Statement of the Society for Phytotherapy (GPT) to the ?Article 13 Health Claim list? of the EFSA Assessment of genotoxicity of herbal medicinal preparations according to the guideline EMEA/HMPC/107079/2007 - A model project of Kooperation Phytopharmaka, Bonn, Germany Implications for an adverse effect of vitamin C in photodynamic therapy Using the nematode caenorhabditis elegans to identify des mode of action of the flavonoid myricetin LowTemperature Plasma ? Mild preservation technology for minimal processed fresh food ? Influence of fumonisin B1 on gene expression and cytokine production Effects of quercetin on the detoxification of the food contaminant benzo[a]pyrene in the human intestinal Caco-2 cell model Risk assessment of T-2 and HT-2 toxin using human cells in primary culture Pyrrolizidine alkaloids in honey bee products Identification of molecular determinants for cytotoxicity of isoliquiritigenin from liquorice (Glycyrrhiza glabra) towards leukemia cell lines Functional effects of polyphenol metabolites produced by colonic microbiota in colon cells Lifelo

InhaltsangabeVorwort/Preface I BERICHT UND SCHLUSSFOLRGERUNGEN II REPORT AND CONCLUSIONS III CONTRIBUTIONS Visions on toxicity testing in the 21st century Safety assessment of botanicals and botanical preparations used as ingredients in food supplements In silico toxicology screening of the rodent carcinogenic potential of phytochemicals using QSAR analysis Testing compuational toxicology models with phytochemicals In silico models to establish level of safety concern in absence of sufficient toxicological data In silico mehtods for physiologically based biokinetic models describing bioactivation and detoxification of coumarin and estragole; implications for risk assessment In vitro models for carcinogenicity testing - reality or fantasy? Carcinogen specific expression profiling: prediction of carcinogenic potential? Safety and biological efficacy testing of phytochemicals: an industry approach Metabolite profiling in rat plasma as a potential new tool for the assessment of chemically induced toxicity Profiling techniques in nutrition and food research The complex links between dietary phytochemicals and human health deciphered by metabolomics Antioxidative and antigenotoxic properties of vegetables and dietary phytochemicals: the value of genomics biomarkers in molecular epidemiology The Japanese toxicogenomics project: application of toxicogenomics Toxicology and risk assessment of coumarin: focus on human data Risk from furocoumarins in food? An exposure assessment Transcriptome analysis in benefit-risk assessment of micronutrients and bioactive food components Colorectal and prostate cancer: The role of candidate genes in nutritional pathways Glucosinolates: DNA adduct formation in vivo and mutagenicity in vitro Defense mechanisms against toxic phytochemicals in the diet of domestic animals POSTERS Coumarin risk assessment: Lessons from human data Coffee and coffee compounds are effective antioxidants in human cells and in vivo Studying absorption, distribution, metabolism, and excretion of a complex extract Polyphenolic apple extracts and their constituents modulate DNA strand breaks and oxidation damage in human colon carcinoma cells Comparative evaluation of experimental data on a-amylase inhibition by flavonoids using molecular modelling Potential risk of furan in foods Comparative study on the toxicity of alternariol and alternariol monomethyl ether in human tumor cells of different origin A role for resveratrol and curcumine in sensitization of glioblastoma cells to genotoxic stress induced by alkylating chemotherapeutics BfRriskassessment of alkaloids as ingredients and contaminants of food: quinine, opium alkaloids, senecio pyrrolizidine alkaloids Elucidation of the genotoxic activity of the alkaloid ellipticine in human cell lines Dietary supplements and herbal medicinal products - for a clear differentiation. Statement of the Society for Phytotherapy (GPT) to the "Article 13 Health Claim list" of the EFSA Assessment of genotoxicity of herbal medicinal preparations according to the guideline EMEA/HMPC/107079/2007 - A model project of Kooperation Phytopharmaka, Bonn, Germany Implications for an adverse effect of vitamin C in photodynamic therapy Using the nematode caenorhabditis elegans to identify des mode of action of the flavonoid myricetin LowTemperature Plasma Mild preservation technology for minimal processed fresh food? Influence of fumonisin B1 on gene expression and cytokine production Effects of quercetin on the detoxification of the food contaminant benzo[a]pyrene in the human intestinal Caco-2 cell model Risk assessment of T-2 and HT-2 toxin using human cells in primary culture Pyrrolizidine alkaloids in honey bee products Identification of molecular determinants for cytotoxicity of isoliquiritigenin from liquorice (Glycyrrhiza glabra) towards leukemia cell lines Functional effects of polyphenol metabolites produced by colonic microbiota in colon cells Lifelong expo